Optical-Switch-Enabled Microfluidics for Sensitive Multichannel Colorimetric Analysis

نویسندگان

چکیده

The implementation of colorimetric analysis within microfluidic environments engenders significant benefits with respect to reduced sample and reagent consumption, system miniaturization, real-time measurement flowing samples. That said, conventional approaches channels are hampered by short optical pathlengths single-channel configurations, which lead poor detection sensitivities low analytical throughputs. Although the use multiplexed light source/photodetector modules allows for multichannel analysis, such configurations significantly increase both instrument complexity cost. To address these issues, we present a four-channel scheme an optical-switch-enabled chip (OSEMC) fabricated two-photon stereolithography. integration switches enables sequential signal readout from each channel, thus, only single source photodetector required operation. Optical can be controlled in bespoke manner changing medium switch channel between “light-transmitting” fluid “light-blocking” using pneumatic microvalves. Such characterized fast response times (approximately 200 ms), tunable switching frequencies (between 0.1 1.0 Hz studied), excellent stability. Operational performance demonstrates good sensitivity reproducibility through nitrite ammonium samples four channels. Furthermore, OSEMC parallel is investigated via characterization adsorption kinetics tartrazine on activated charcoal catalytic reaction horseradish peroxidase (HRP).

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ژورنال

عنوان ژورنال: Analytical Chemistry

سال: 2021

ISSN: ['1520-6882', '0003-2700']

DOI: https://doi.org/10.1021/acs.analchem.1c00674